Hereditary spherocytosis (HS) and sickle cell disease (SCD) are associated with splenomegaly and spleen dysfunction in pediatric patients. Scant data exist on possible correlations between spleen morphology and function in HS and SCD. This study aimed to assess the histological and morphometric features of HS and SCD spleens, in order to get possible correlations with disease pathophysiology. In a large series of spleens from SCD, HS and control patients the following parameters were considered: (i) macroscopic features; (ii) lymphoid follicle (LF) density; (iii) presence of peri-follicular marginal zones (MZs); (iv) presence of Gamna-Gandy bodies; (v) density of CD8-positive sinusoids; (vi) density of CD34-positive microvessels; (vii) pres...
Background: Spleen is commonly involved in sickle cell disease (SCD), and splenic abnormalities are ...
La drépanocytose est une maladie génétique du globule rouge (GR), due à une mutation ponctuelle du g...
Hereditary spherocytosis is a clinically heterogeneous, genetically determined red blood cell membra...
Hereditary spherocytosis (HS) and sickle cell disease (SCD) are associated with splenomegaly and spl...
Sickle cell disease (SCD) is caused by a point mutation in the beta-globin gene. SCD is characterize...
Sickle cell disease (SCD) is caused by a point mutation in the beta-globin gene. SCD is characterize...
Sickle cell disease (SCD) is a condition of functional hypo‐/a‐splenism in which predisposition to b...
Sickle cell disease (SCD) is a condition of functional hypo‐/a‐splenism in which predisposition to b...
The majority of the global population of sickle cell disease (SCD) patients resides in Africa. Indiv...
Although functional asplenia from infarctions may be a major contributor to increased infectious mor...
ObjectiveIn patients with sickle cell disease (SCD), the spleen commonly enlarges during early child...
BackgroundAlthough loss of splenic function is the expected natural course for individuals with sick...
In a study of the natural history of homozygous sickle cell (SS) disease 154 of 160 Jamaican childre...
Background: The spleen serves critical haematological and immunological functions in the body. Howev...
In a study of the natural history of homozygous sickle cell (SS) disease 154 of 160 Jamaican childre...
Background: Spleen is commonly involved in sickle cell disease (SCD), and splenic abnormalities are ...
La drépanocytose est une maladie génétique du globule rouge (GR), due à une mutation ponctuelle du g...
Hereditary spherocytosis is a clinically heterogeneous, genetically determined red blood cell membra...
Hereditary spherocytosis (HS) and sickle cell disease (SCD) are associated with splenomegaly and spl...
Sickle cell disease (SCD) is caused by a point mutation in the beta-globin gene. SCD is characterize...
Sickle cell disease (SCD) is caused by a point mutation in the beta-globin gene. SCD is characterize...
Sickle cell disease (SCD) is a condition of functional hypo‐/a‐splenism in which predisposition to b...
Sickle cell disease (SCD) is a condition of functional hypo‐/a‐splenism in which predisposition to b...
The majority of the global population of sickle cell disease (SCD) patients resides in Africa. Indiv...
Although functional asplenia from infarctions may be a major contributor to increased infectious mor...
ObjectiveIn patients with sickle cell disease (SCD), the spleen commonly enlarges during early child...
BackgroundAlthough loss of splenic function is the expected natural course for individuals with sick...
In a study of the natural history of homozygous sickle cell (SS) disease 154 of 160 Jamaican childre...
Background: The spleen serves critical haematological and immunological functions in the body. Howev...
In a study of the natural history of homozygous sickle cell (SS) disease 154 of 160 Jamaican childre...
Background: Spleen is commonly involved in sickle cell disease (SCD), and splenic abnormalities are ...
La drépanocytose est une maladie génétique du globule rouge (GR), due à une mutation ponctuelle du g...
Hereditary spherocytosis is a clinically heterogeneous, genetically determined red blood cell membra...