Association of genetic polymorphisms with survival of pancreatic ductal adenocarcinoma patients
- Rizzato, C
- Campa, D
- Talar Wojnarowska, R
- Halloran, C
- Kupcinskas, J
- Butturini, G
- Moheln\uedkov\ue1 Ducho\u148ov\ue1, B
- Sperti, Cosimo
- Tjaden, C
- Ghaneh, P
- Hackert, T
- Funel, N
- Giese, N
- Tavano, F
- Pezzilli, R
- Pedata, M
- Pasquali, Claudio
- Gazouli, M
- Mambrini, A
- Sou\u10dek, P
- di Sebastiano, P
- Capurso, G
- Cantore, M
- Oliverius, M
- Offringa, R
- Ma\u142ecka Panas, E
- Strobel, O
- Scarpa, A
- Canzian, F.
DOIAbstract
Germline genetic variability might contribute, at least partially, to the survival of pancreatic ductal adenocarcinoma (PDAC) patients. Two recently performed genome-wide association studies (GWAS) on PDAC overall survival (OS) suggested (p<10-5) the association between 30 genomic regions and PDAC OS. With the aim to highlight the true associations within these regions, we analysed 44 single-nucleotide polymorphisms (SNPs) in the 30 candidate regions in 1722 PDAC patients within the PANcreatic Disease ReseArch (PANDoRA) consortium. We observed statistically significant associations for five of the selected regions. One association in the CTNNA2 gene on chromosome 2p12 (rs1567532, HR=1.75, 95% CI 1.19-2.58, p=0.005 for homozygotes for the mi...
Add to ORKG