Signal transducer and activator of transcription 3 (STAT3) and phosphatase and tensin homologue (PTEN) are, respectively, an oncogene and tumour suppressor gene whose dysregulated expression in human prostate cancer is associated with increased malignancy and poor prognosis. Both markers were evaluated in 12 samples of canine benign prostatic hyperplasia (BPH) and 17 canine prostatic carcinomas (PCs) by immunohistochemistry, to understand their possible role in canine prostate carcinogenesis. STAT3 was expressed in 25% and 82.35% of BPH and PC, respectively, with a significantly higher number of STAT3-positive cells in malignant compared with hyperplastic lesions. Three PCs had occasional nuclear expression of STAT3. PTEN was expressed in B...
Controversies remain regarding the cell type from which human prostate cancer originates, and many a...
In this report, we describe the development of a transgenic mouse in which a rat probasin promoter (...
Phosphatase and tensin homolog (PTEN) belong to the group of gatekeepers tumour suppressor genes and...
Signal transducer and activator of transcription 3 (STAT3) and phosphatase and tensin homologue (PTE...
ABSTRACT: Canine prostate gland is a hormonal dependent organ and its imbalance of estrogen and andr...
The canis lupus familiares is the only species besides human that spontaneously develop prostatic ca...
<div><p>An unusual variant of prostate adenocarcinoma (PC) expressing nuclear p63 in secretory cells...
An unusual variant of prostate adenocarcinoma (PC) expressing nuclear p63 in secretory cells instead...
<p>(A) Normal prostatic tissue presented strong expression of NKX3.1. All p63+ and p63- PCs were neg...
Prostate cancer (PCa) in dogs is a highly malignant disease akin to its human counterpart. In contra...
Abstract PTEN is one of the most commonly deleted/mutated tumor suppressor genes in human prostate c...
The development of prostate cancer is believed to be a multistep process, progressing sequentially f...
Abstract. Canine osteosarcoma (OS) cell lines contain mutations that directly or indirectly inactiva...
Canine prostatic carcinoma (PCa) is considered a relevant model for studying advanced, hormone refra...
Prostate Cancer (PCa) is a complex and heterogeneous disease. The androgen receptor (AR) and the sig...
Controversies remain regarding the cell type from which human prostate cancer originates, and many a...
In this report, we describe the development of a transgenic mouse in which a rat probasin promoter (...
Phosphatase and tensin homolog (PTEN) belong to the group of gatekeepers tumour suppressor genes and...
Signal transducer and activator of transcription 3 (STAT3) and phosphatase and tensin homologue (PTE...
ABSTRACT: Canine prostate gland is a hormonal dependent organ and its imbalance of estrogen and andr...
The canis lupus familiares is the only species besides human that spontaneously develop prostatic ca...
<div><p>An unusual variant of prostate adenocarcinoma (PC) expressing nuclear p63 in secretory cells...
An unusual variant of prostate adenocarcinoma (PC) expressing nuclear p63 in secretory cells instead...
<p>(A) Normal prostatic tissue presented strong expression of NKX3.1. All p63+ and p63- PCs were neg...
Prostate cancer (PCa) in dogs is a highly malignant disease akin to its human counterpart. In contra...
Abstract PTEN is one of the most commonly deleted/mutated tumor suppressor genes in human prostate c...
The development of prostate cancer is believed to be a multistep process, progressing sequentially f...
Abstract. Canine osteosarcoma (OS) cell lines contain mutations that directly or indirectly inactiva...
Canine prostatic carcinoma (PCa) is considered a relevant model for studying advanced, hormone refra...
Prostate Cancer (PCa) is a complex and heterogeneous disease. The androgen receptor (AR) and the sig...
Controversies remain regarding the cell type from which human prostate cancer originates, and many a...
In this report, we describe the development of a transgenic mouse in which a rat probasin promoter (...
Phosphatase and tensin homolog (PTEN) belong to the group of gatekeepers tumour suppressor genes and...