AAZTA: An Ideal Chelating Agent for the Development of 44Sc PET Imaging Agents
- Nagy, G.
- Szikra, D.
- Trencsényi, G.
- Fekete, A.
- Garai, I.
- Giani, A. M.
- Negri, R.
- Maiocchi, A.
- Uggeri, F.
- Toth, I.
- Aime, S.
- Giovenzana, G. B.
- Baranyai, Z.
- MASCIOCCHI, NORBERTO
DOIAbstract
Unprecedented fast and efficient complexation of ScIII was demonstrated with the chelating agent AAZTA (AAZTA=1,4-bis(carboxymethyl)-6-[bis(carboxymethyl)]amino-6-methylperhydro-1,4-diazepine) under mild experimental conditions. The robustness of the 44 Sc(AAZTA)- chelate and conjugated biomolecules thereof is further shown by in vivo PET imaging in healthy and tumor mice models. The new results pave the way towards development of efficient Sc-based radiopharmaceuticals using the AAZTA chelator
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