Add to ORKGInternational audienceSjögren's syndrome (SS) or autoimmune epithelitis is characterized by focal lymphocytic infiltrates surrounding the tubular epithelium of exocrine glands and by overactivity of the B-cell population. Although T cells were long considered the main effectors in SS, recent findings indicating a key role for B cells have prompted studies of treatments designed to deplete the B-cell population. Among molecules that can be targeted to achieve B-cell depletion, CD20 and CD22 are surface antigens expressed specifically by B lymphocytes; and the cytokine B-cell-activating factor belonging to the TNF family (BAFF) is a TNF receptor ligand involved in B-cell differentiation, survival, and activation. The aim of this review is to ...
Treatment of Sjgren's syndrome has been largely empiric, aimed mainly at alleviation of sicca c...
In vitro and in vivo experimental data have pointed to new immunopathogenic mechanisms in primary Sj...
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder affecting exocrine glands of the b...
International audiencePrimary Sjögren's syndrome is a systemic autoimmune disease characterized by p...
International audienceSjögren's syndrome (SS) is an autoimmune epithelitis. This exocrinopathy is fr...
International audiencePrimary Sjögren's syndrome (pSS) is a chronic autoimmune systemic disease, cha...
Primary Sjögren's syndrome (pSS) is an autoimmune exocrinopathy characterized by chronic inflammatio...
International audienceThe autoimmune exocrinopathy Sjögren's syndrome (SS) is characterized by monon...
International audienceSjögren's syndrome (SS) is an autoimmune epithelitis hallmarked by a destructi...
T cells have long occupied central stage of the debate on the type of lymphocytes involved in the pa...
Sjogren?s syndrome (SS) is an autoimmune disorder characterised by lymphocytic infiltration of exocr...
OBJECTIVE: B-cell expansion is a key feature of Sjögren's syndrome (SS). Accordingly, several studie...
International audienceT cells have originally occupied central stage of the debate on the type of ly...
International audienceBiological abnormalities associated with B lymphocytes are a hallmark of patie...
Despite the well-established role of B cells in the pathogenesis of primary Sjögren's syndrome (pSS)...
Treatment of Sjgren's syndrome has been largely empiric, aimed mainly at alleviation of sicca c...
In vitro and in vivo experimental data have pointed to new immunopathogenic mechanisms in primary Sj...
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder affecting exocrine glands of the b...
International audiencePrimary Sjögren's syndrome is a systemic autoimmune disease characterized by p...
International audienceSjögren's syndrome (SS) is an autoimmune epithelitis. This exocrinopathy is fr...
International audiencePrimary Sjögren's syndrome (pSS) is a chronic autoimmune systemic disease, cha...
Primary Sjögren's syndrome (pSS) is an autoimmune exocrinopathy characterized by chronic inflammatio...
International audienceThe autoimmune exocrinopathy Sjögren's syndrome (SS) is characterized by monon...
International audienceSjögren's syndrome (SS) is an autoimmune epithelitis hallmarked by a destructi...
T cells have long occupied central stage of the debate on the type of lymphocytes involved in the pa...
Sjogren?s syndrome (SS) is an autoimmune disorder characterised by lymphocytic infiltration of exocr...
OBJECTIVE: B-cell expansion is a key feature of Sjögren's syndrome (SS). Accordingly, several studie...
International audienceT cells have originally occupied central stage of the debate on the type of ly...
International audienceBiological abnormalities associated with B lymphocytes are a hallmark of patie...
Despite the well-established role of B cells in the pathogenesis of primary Sjögren's syndrome (pSS)...
Treatment of Sjgren's syndrome has been largely empiric, aimed mainly at alleviation of sicca c...
In vitro and in vivo experimental data have pointed to new immunopathogenic mechanisms in primary Sj...
Primary Sjögren's syndrome (pSS) is a chronic autoimmune disorder affecting exocrine glands of the b...