International audienceThe synthesis of new C-6 1,2,3-triazole adenosine derivatives via microwave assisted 1,3-dipolar cycloaddition as key step is described. The binding on membranes of cells that over express A1 adenosine receptors (A1AR) was also evaluated. Among them, four compounds increased cAMP production, in a dose-dependent manner acting as antagonists of the A1AR, while two compounds act as agonists
A new series of pyrazolotriazolopyrimidines bearing different substitutions on the phenylcarbamoyl m...
The synthesis of 9-alkyl substituted adenine derivatives presenting aromatic groups and cycloalkyl r...
Title compds. represented by the formula I [wherein W = (un)substituted (hetero)aryl; R1 = H, (un)su...
International audienceThe synthesis of new C-6 1,2,3-triazole adenosine derivatives via microwave as...
Adenosine is an endogenous purine nucleoside that play a key role in numerous important physiologica...
A number of adenosine analogues substituted in the 2- and N6-positions were synthesized and evaluate...
New derivatives of PD 81,723, an allosteric enhancer of agonist binding to the A1-adenosine receptor...
This paper reports the synthesis and biological evaluation towards Al and A2 adenosine receptors of ...
Adenosine receptors (ARs) belong to the G protein-coupled receptor (GPCR) family, and can be subdivi...
The synthesis of a new family of A1-adenosine receptor (A1AR) ligands has was performed in a straigh...
Novel 3,8- and 8,9-disubstituted N6-cyclopentyladenine derivatives were synthesised in moderate over...
This paper reports the continuation of studies on the 4-aminosubstituted 1,2,3-triazolo [4,5-d] pyri...
The synthesis of a new family of A1-adenosine receptor (A1AR) ligands 3a-n has been performed in a s...
The synthesis and biological evaluation of N6, C8-disubstituted derivatives of adenosine as potentia...
A new series of triazolo-triazine differently substituted at the C5 and N7 positions have been synth...
A new series of pyrazolotriazolopyrimidines bearing different substitutions on the phenylcarbamoyl m...
The synthesis of 9-alkyl substituted adenine derivatives presenting aromatic groups and cycloalkyl r...
Title compds. represented by the formula I [wherein W = (un)substituted (hetero)aryl; R1 = H, (un)su...
International audienceThe synthesis of new C-6 1,2,3-triazole adenosine derivatives via microwave as...
Adenosine is an endogenous purine nucleoside that play a key role in numerous important physiologica...
A number of adenosine analogues substituted in the 2- and N6-positions were synthesized and evaluate...
New derivatives of PD 81,723, an allosteric enhancer of agonist binding to the A1-adenosine receptor...
This paper reports the synthesis and biological evaluation towards Al and A2 adenosine receptors of ...
Adenosine receptors (ARs) belong to the G protein-coupled receptor (GPCR) family, and can be subdivi...
The synthesis of a new family of A1-adenosine receptor (A1AR) ligands has was performed in a straigh...
Novel 3,8- and 8,9-disubstituted N6-cyclopentyladenine derivatives were synthesised in moderate over...
This paper reports the continuation of studies on the 4-aminosubstituted 1,2,3-triazolo [4,5-d] pyri...
The synthesis of a new family of A1-adenosine receptor (A1AR) ligands 3a-n has been performed in a s...
The synthesis and biological evaluation of N6, C8-disubstituted derivatives of adenosine as potentia...
A new series of triazolo-triazine differently substituted at the C5 and N7 positions have been synth...
A new series of pyrazolotriazolopyrimidines bearing different substitutions on the phenylcarbamoyl m...
The synthesis of 9-alkyl substituted adenine derivatives presenting aromatic groups and cycloalkyl r...
Title compds. represented by the formula I [wherein W = (un)substituted (hetero)aryl; R1 = H, (un)su...