International audienceDespite the importance of phages in driving horizontal gene transfer (HGT) among pathogenic bacteria, the underlying molecular mechanisms mediating phage adsorption to S. aureus are still unclear. Phage ϕ11 is a siphovirus with a high transducing efficiency. Here, we show that the tail protein Gp45 localized within the ϕ11 baseplate. Phage ϕ11 was efficiently neutralized by anti-Gp45 serum and its adsorption to host cells was inhibited by recombinant Gp45 in a dose-dependent manner. Flow cytometry analysis demonstrated that biotin-labelled Gp45 efficiently stained the wild-type S. aureus cell but not the double knockout mutant ΔtarM/S, which lacks both α- and β-O-GlcNAc residues on its wall teichoic acids (WTAs). Addit...
Antibiotic-resistant bacteria present a severe threat to global health. The future treatment of comm...
Bacteriophages play a major role in spreading mobile genetic elements (MGEs)-encoded genes among bac...
Bacteriophage (phage) therapy is a promising alternative to antibiotics for the treatment of bacteri...
International audienceDespite the importance of phages in driving horizontal gene transfer (HGT) amo...
International audiencePhages play key roles in the pathogenicity and adaptation of the human pathoge...
ABSTRACT 22 The molecular interactions between staphylococcal phages and host cell surfaces are poor...
The phage life cycle is initiated by the interaction between viral proteins and specific receptor at...
Recognition of the bacterial host and attachment to its surface are two critical steps in phage infe...
Mobile genetic elements (MGEs) encoding virulence and resistance genes are widespread in bacterial p...
Adsorption of a bacteriophage to the host requires recognition of a cell wall-associated receptor by...
AbstractAdsorption of a bacteriophage to the host requires recognition of a cell wall-associated rec...
The inherent ability of bacteriophages (phages) to infect specific bacterial hosts makes them ideal ...
Many staphylococcal bacteriophages encode a minor capsid protein between the genes for the portal an...
Targeting conserved and essential processes is a successful strategy to combat enemies. Remarkably, ...
Clostridium difficile causes severe infectious diarrhoea referred to as C. difficile infection (CDI)...
Antibiotic-resistant bacteria present a severe threat to global health. The future treatment of comm...
Bacteriophages play a major role in spreading mobile genetic elements (MGEs)-encoded genes among bac...
Bacteriophage (phage) therapy is a promising alternative to antibiotics for the treatment of bacteri...
International audienceDespite the importance of phages in driving horizontal gene transfer (HGT) amo...
International audiencePhages play key roles in the pathogenicity and adaptation of the human pathoge...
ABSTRACT 22 The molecular interactions between staphylococcal phages and host cell surfaces are poor...
The phage life cycle is initiated by the interaction between viral proteins and specific receptor at...
Recognition of the bacterial host and attachment to its surface are two critical steps in phage infe...
Mobile genetic elements (MGEs) encoding virulence and resistance genes are widespread in bacterial p...
Adsorption of a bacteriophage to the host requires recognition of a cell wall-associated receptor by...
AbstractAdsorption of a bacteriophage to the host requires recognition of a cell wall-associated rec...
The inherent ability of bacteriophages (phages) to infect specific bacterial hosts makes them ideal ...
Many staphylococcal bacteriophages encode a minor capsid protein between the genes for the portal an...
Targeting conserved and essential processes is a successful strategy to combat enemies. Remarkably, ...
Clostridium difficile causes severe infectious diarrhoea referred to as C. difficile infection (CDI)...
Antibiotic-resistant bacteria present a severe threat to global health. The future treatment of comm...
Bacteriophages play a major role in spreading mobile genetic elements (MGEs)-encoded genes among bac...
Bacteriophage (phage) therapy is a promising alternative to antibiotics for the treatment of bacteri...