A Lab-On-Chip system with an instrument is presented which is capable of performing total sample preparation and automated extraction of nucleic acid from human cell samples fixed in a methanol based solution. The target application is extraction of mRNA from cervical liquid based cytology specimens for detection of transformed HPV-infections. The device accepts 3 ml of sample and performs the extraction in a disposable polymer chip of credit card size. All necessary reagents for cell lysis, washing, and elution are stored on-chip and the extraction is performed in two filter stages; one for cell pre-concentration and the other for nucleic acid capture. Tests performed using cancer cell lines and cervical liquid based cytology specimens con...
Lab-on-a-chip systems can be used to conduct various biological and chemical processes for point-of-...
ABSTRACT: Preparation of raw, untreated biological samples remains a major challenge in microfluidic...
Many new and exciting portable HIV viral load testing technologies are emerging for use in global me...
A Lab-On-Chip system with an instrument is presented which is capable of performing total sample pre...
Cervical cancer affects over half a million people worldwide each year, the majority of whom are in ...
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction...
In this work, we focused on the development of a novel point of care (POC) paper-based analytical mi...
Aim: Processing of the samples in molecular diagnostics is complex and labor-intensive. An integrate...
Nucleic acid (NA) extraction is a basic step for genetic analysis, from scientific research to diagn...
The result of molecular diagnostic and detection greatly dependent on the quality and integrity of t...
Sample preparation is an essential process that precedes nucleic acid detections which use quantitat...
Nucleic acid extraction is vital in many applications such as molecular diagnostics, genetic enginee...
Urine is a preferred specimen for nucleic acid-based detection of sexually transmitted infections (S...
Residual material from liquid-based cytology (LBC) samples, collected during cervical screening, is ...
Purification of nucleic acids from a low quantity of bacterial cells in minute volume is important i...
Lab-on-a-chip systems can be used to conduct various biological and chemical processes for point-of-...
ABSTRACT: Preparation of raw, untreated biological samples remains a major challenge in microfluidic...
Many new and exciting portable HIV viral load testing technologies are emerging for use in global me...
A Lab-On-Chip system with an instrument is presented which is capable of performing total sample pre...
Cervical cancer affects over half a million people worldwide each year, the majority of whom are in ...
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction...
In this work, we focused on the development of a novel point of care (POC) paper-based analytical mi...
Aim: Processing of the samples in molecular diagnostics is complex and labor-intensive. An integrate...
Nucleic acid (NA) extraction is a basic step for genetic analysis, from scientific research to diagn...
The result of molecular diagnostic and detection greatly dependent on the quality and integrity of t...
Sample preparation is an essential process that precedes nucleic acid detections which use quantitat...
Nucleic acid extraction is vital in many applications such as molecular diagnostics, genetic enginee...
Urine is a preferred specimen for nucleic acid-based detection of sexually transmitted infections (S...
Residual material from liquid-based cytology (LBC) samples, collected during cervical screening, is ...
Purification of nucleic acids from a low quantity of bacterial cells in minute volume is important i...
Lab-on-a-chip systems can be used to conduct various biological and chemical processes for point-of-...
ABSTRACT: Preparation of raw, untreated biological samples remains a major challenge in microfluidic...
Many new and exciting portable HIV viral load testing technologies are emerging for use in global me...