International audienceCitronellyl- and solanesyl-based dolichol linked oligosaccharide (DLO) analogs were synthesized and tested along with undecaprenyl compounds for their ability to inhibit the release of [(3)H]OSP from [(3)H]DLO by mammalian liver DLO diphosphatase activity. Solanesyl (C45) and undecaprenyl (C55) compounds were 50-500 fold more potent than their citronellyl (C10)-based counterparts, indicating that the alkyl chain length is important for activity. The relative potency of the compounds within the citronellyl series was different to that of the solanesyl series with citronellyl diphosphate being 2 and 3 fold more potent than citronellyl-PP-GlcNAc2 and citronellyl-PP-GlcNAc, respectively; whereas solanesyl-PP-GlcNAc and sol...
Antibiotic resistance is a serious threat against humankind and the need for new therapeutics is cru...
To elucidate the mechanism of the reaction catalyzed by yeast oligosaccharyl-transferase (OST, E.C. ...
In the majority of congenital disorders of glycosylation, the assembly of the glycan precursor GlcNA...
International audienceCitronellyl- and solanesyl-based dolichol linked oligosaccharide (DLO) analogs...
International audienceMammalian protein N-glycosylation requires the transfer of an oligosaccharide ...
The dolichol-linked oligosaccharide donor (Glc(3)Man(9)GlcNAc(2)-PP-Dol) for N-linked glycosylation ...
Mammalian protein N-glycosylation requires the transfer of an oligosaccharide containing 2 residues ...
<p>The dolichol cycle consists of a series of reactions (heavy dashed blue lines) involved in the co...
The phosphorylated derivatives of dolichol are essential intermediates in the biosynthesis of aspara...
Incubation of mouse myeloma microsomes with GDP-[(14)C]mannose results in the biosynthesis of [(14)C...
CONTEXTE: Les " Type I Congenital disorders of glycosylation " (CDG-I) comportent des déficits de bi...
Several methods for simple and efficient chemical synthesis of dolichyl phosphates and their analogu...
Dolichol is one of the mevalonate pathway end products, present in all tissues and cellular membrane...
Antibiotic resistance is a serious threat against humankind and the need for new therapeutics is cru...
To elucidate the mechanism of the reaction catalyzed by yeast oligosaccharyl-transferase (OST, E.C. ...
In the majority of congenital disorders of glycosylation, the assembly of the glycan precursor GlcNA...
International audienceCitronellyl- and solanesyl-based dolichol linked oligosaccharide (DLO) analogs...
International audienceMammalian protein N-glycosylation requires the transfer of an oligosaccharide ...
The dolichol-linked oligosaccharide donor (Glc(3)Man(9)GlcNAc(2)-PP-Dol) for N-linked glycosylation ...
Mammalian protein N-glycosylation requires the transfer of an oligosaccharide containing 2 residues ...
<p>The dolichol cycle consists of a series of reactions (heavy dashed blue lines) involved in the co...
The phosphorylated derivatives of dolichol are essential intermediates in the biosynthesis of aspara...
Incubation of mouse myeloma microsomes with GDP-[(14)C]mannose results in the biosynthesis of [(14)C...
CONTEXTE: Les " Type I Congenital disorders of glycosylation " (CDG-I) comportent des déficits de bi...
Several methods for simple and efficient chemical synthesis of dolichyl phosphates and their analogu...
Dolichol is one of the mevalonate pathway end products, present in all tissues and cellular membrane...
Antibiotic resistance is a serious threat against humankind and the need for new therapeutics is cru...
To elucidate the mechanism of the reaction catalyzed by yeast oligosaccharyl-transferase (OST, E.C. ...
In the majority of congenital disorders of glycosylation, the assembly of the glycan precursor GlcNA...