International audienceCell populations with differing proliferative, stem-like and tumorigenic states co-exist in most tumors and especially malignant gliomas. Whether metabolic variations can drive this heterogeneity by controlling dynamic changes in cell states is unknown. Metabolite profiling of human adult glioblastoma stem-like cells upon loss of their tumorigenicity revealed a switch in the catabolism of the GABA neurotransmitter toward enhanced production and secretion of its by-product GHB (4-hydroxybutyrate).This switch was driven by succinic semialdehyde dehydrogenase (SSADH) downregulation. Enhancing GHB levels via SSADH downregulation or GHB supplementation triggered cell conversion into a less aggressive phenotypic state. GHB a...
International audienceOver the years, substantial evidence has definitively confirmed the existence ...
Abstract Background Glioblastoma is the most frequent...
International audienceOver the years, substantial evidence has definitively confirmed the existence ...
International audienceCell populations with differing proliferative, stem-like and tumorigenic state...
International audienceCell populations with differing proliferative, stem-like and tumorigenic state...
International audienceCell populations with differing proliferative, stem-like and tumorigenic state...
Cell populations with differing proliferative, stem-like and tumorigenic states co-exist in most tum...
International audienceCell populations with differing proliferative, stem-like and tumorigenic state...
Abstract Background Bioenergetic characterisation of malignant tissues revealed that different tumou...
Gliomas are the most common malignant brain tumours. The most aggressive and lethal type of glioma i...
Bioenergetic characterisation of malignant tissues revealed that different tumour cells can cataboli...
Bioenergetic characterisation of malignant tissues revealed that different tumour cells can cataboli...
Glioblastoma multiforme (GBM), or grade IV astrocytoma, is the most common type of primary brain tum...
Glioblastoma multiforme (GBM), or grade IV astrocytoma, is the most common type of primary brain tum...
Glioblastoma (GBM) remains the most common and lethal primary brain tumor in adults despite concerte...
International audienceOver the years, substantial evidence has definitively confirmed the existence ...
Abstract Background Glioblastoma is the most frequent...
International audienceOver the years, substantial evidence has definitively confirmed the existence ...
International audienceCell populations with differing proliferative, stem-like and tumorigenic state...
International audienceCell populations with differing proliferative, stem-like and tumorigenic state...
International audienceCell populations with differing proliferative, stem-like and tumorigenic state...
Cell populations with differing proliferative, stem-like and tumorigenic states co-exist in most tum...
International audienceCell populations with differing proliferative, stem-like and tumorigenic state...
Abstract Background Bioenergetic characterisation of malignant tissues revealed that different tumou...
Gliomas are the most common malignant brain tumours. The most aggressive and lethal type of glioma i...
Bioenergetic characterisation of malignant tissues revealed that different tumour cells can cataboli...
Bioenergetic characterisation of malignant tissues revealed that different tumour cells can cataboli...
Glioblastoma multiforme (GBM), or grade IV astrocytoma, is the most common type of primary brain tum...
Glioblastoma multiforme (GBM), or grade IV astrocytoma, is the most common type of primary brain tum...
Glioblastoma (GBM) remains the most common and lethal primary brain tumor in adults despite concerte...
International audienceOver the years, substantial evidence has definitively confirmed the existence ...
Abstract Background Glioblastoma is the most frequent...
International audienceOver the years, substantial evidence has definitively confirmed the existence ...