The combination of ethosuximlde and vaiproate has been advo- due to a less than additive neurotoxic interaction, the comna-cated, partioularly in patients wfth atycai and myoclonic ab- tion had a better efficacy vs. todcfty score than either drug alone. sences. This drug combination has been assessed expetimen- These results, although not representative for all drug combine-tally In mice by studying the effect of the pharrnacodynamlc tions, provide evidence that the dissociation between the anti-interactions between the two drugs on the efficacy vs. toxlcfty convulsant and the neurotoxic interaction of two antiepileptic ratio. All results were expressed In terms of brain concentrations. drugs can resuft In a better protective index for cert...
Purpose: When monotherapy with antiepileptic drugs (AEDs) fails, combination therapy is tried so as ...
Depression is becoming a growing problem in rural areas. This psychiatric disorder often accompanies...
Antiepiletic drugs are about equally efficacious in suppressing epileptic seizures,however they do d...
Most patients with newly diagnosed epilepsy can be optimally controlled by prescribing a single anti...
Background: Approximately 50% of patients do not achieve seizure control with antiepileptic drug (AE...
The experimental and clinical evidence in support of “rational polytherapy” is sparse, and to date, ...
The global introduction of 14 new antiepileptic drugs (AEDs) over the past 20 years as adjunctive tr...
There is emerging evidence to support the efficacy of some antiepileptic drug (AED) combinations in ...
The development of assays for plasma antiepileptic drug concentrations has led to the discovery of m...
AbstractThe global introduction of 14 new antiepileptic drugs (AEDs) over the past 20 years as adjun...
Objective: We studied the interaction between valproate (VPA) and ethosuximide (ESM) in diminishing ...
Lacosamide (LCM, Vimpat) is an anticonvulsant with a unique mode of action. This provides lacosamide...
AbstractThere is emerging evidence to support the efficacy of some antiepileptic drug (AED) combinat...
Anti-epileptic drugs frequently interact due to pharmacokinetic features (induction or inhibition of...
The aim of the present study was to characterize the anticonvulsant effects of levetiracetam in comb...
Purpose: When monotherapy with antiepileptic drugs (AEDs) fails, combination therapy is tried so as ...
Depression is becoming a growing problem in rural areas. This psychiatric disorder often accompanies...
Antiepiletic drugs are about equally efficacious in suppressing epileptic seizures,however they do d...
Most patients with newly diagnosed epilepsy can be optimally controlled by prescribing a single anti...
Background: Approximately 50% of patients do not achieve seizure control with antiepileptic drug (AE...
The experimental and clinical evidence in support of “rational polytherapy” is sparse, and to date, ...
The global introduction of 14 new antiepileptic drugs (AEDs) over the past 20 years as adjunctive tr...
There is emerging evidence to support the efficacy of some antiepileptic drug (AED) combinations in ...
The development of assays for plasma antiepileptic drug concentrations has led to the discovery of m...
AbstractThe global introduction of 14 new antiepileptic drugs (AEDs) over the past 20 years as adjun...
Objective: We studied the interaction between valproate (VPA) and ethosuximide (ESM) in diminishing ...
Lacosamide (LCM, Vimpat) is an anticonvulsant with a unique mode of action. This provides lacosamide...
AbstractThere is emerging evidence to support the efficacy of some antiepileptic drug (AED) combinat...
Anti-epileptic drugs frequently interact due to pharmacokinetic features (induction or inhibition of...
The aim of the present study was to characterize the anticonvulsant effects of levetiracetam in comb...
Purpose: When monotherapy with antiepileptic drugs (AEDs) fails, combination therapy is tried so as ...
Depression is becoming a growing problem in rural areas. This psychiatric disorder often accompanies...
Antiepiletic drugs are about equally efficacious in suppressing epileptic seizures,however they do d...