Add to ORKGA variety of radiolabeled somatostatin analogs have been developed for targeting of somatostatin receptor (sst)–positive tumors. Bicyclic somatostatin-based radiopeptides have not been studied yet. Hypothesizing that the introduction of confor-mational constraints may lead to receptor subtype selectivity or may help to delineate structural features determining pansoma-tostatin potency, we developed and evaluated first examples of this new class of potential radiotracers for imaging or therapy of neuroendocrine tumors. Methods: The bicyclic peptides were synthesized by standard solid-phase peptide synthesis. DOTA was coupled to the resin-assembled peptide for labeling with 177Lu and 68Ga. Binding affinity and receptor subtype profile were de...
Item does not contain fulltextPeptide-based radiopharmaceuticals have been introduced into clinical ...
Receptors for regulatory peptides are overexpressed in a variety of human cancers. They represent th...
Somatostatin (SST) is a 28-amino-acid cyclic neuropeptide mainly secreted by neurons and endocrine c...
A variety of radiolabeled somatostatin analogs have been developed for targeting of somatostatin rec...
A variety of radiolabeled somatostatin analogs have been developed for targeting of somatostatin rec...
Radiolabeled somatostatin analogs have become powerful tools in the diagnosis and staging of neuroen...
Radiolabeled somatostatin analogues are routinely used for the detection of neuroendocrine tumors (N...
SummaryThe prototypes for tumor targeting with radiolabeled peptides are derivatives of somatostatin...
International audienceIdentified in 1973, somatostatin (SST) is a cyclic hormone peptide with a shor...
The prototypes for tumor targeting with radiolabeled peptides are derivatives of somatostatin. Usual...
Peptides have good characteristics as radiopharmaceuticals: they are small in size and have a fast r...
textabstractPeptide receptor radionuclide therapy (PRRT) has been shown to be an effective treatment...
Molecular imaging plays an essential role in balancing the clinical benefits and risks of radionucli...
ABSTRACT: On their plasma membranes, cells express receptor proteins with high affinity for regulato...
PURPOSE: Somatostatin receptor (sst) targeting is an established method to image and treat sst-posit...
Item does not contain fulltextPeptide-based radiopharmaceuticals have been introduced into clinical ...
Receptors for regulatory peptides are overexpressed in a variety of human cancers. They represent th...
Somatostatin (SST) is a 28-amino-acid cyclic neuropeptide mainly secreted by neurons and endocrine c...
A variety of radiolabeled somatostatin analogs have been developed for targeting of somatostatin rec...
A variety of radiolabeled somatostatin analogs have been developed for targeting of somatostatin rec...
Radiolabeled somatostatin analogs have become powerful tools in the diagnosis and staging of neuroen...
Radiolabeled somatostatin analogues are routinely used for the detection of neuroendocrine tumors (N...
SummaryThe prototypes for tumor targeting with radiolabeled peptides are derivatives of somatostatin...
International audienceIdentified in 1973, somatostatin (SST) is a cyclic hormone peptide with a shor...
The prototypes for tumor targeting with radiolabeled peptides are derivatives of somatostatin. Usual...
Peptides have good characteristics as radiopharmaceuticals: they are small in size and have a fast r...
textabstractPeptide receptor radionuclide therapy (PRRT) has been shown to be an effective treatment...
Molecular imaging plays an essential role in balancing the clinical benefits and risks of radionucli...
ABSTRACT: On their plasma membranes, cells express receptor proteins with high affinity for regulato...
PURPOSE: Somatostatin receptor (sst) targeting is an established method to image and treat sst-posit...
Item does not contain fulltextPeptide-based radiopharmaceuticals have been introduced into clinical ...
Receptors for regulatory peptides are overexpressed in a variety of human cancers. They represent th...
Somatostatin (SST) is a 28-amino-acid cyclic neuropeptide mainly secreted by neurons and endocrine c...