The Effect of Histocompatibility Matching on

ABSTRACT: The value of histocompatibility match-ing in frozen bone allografts was studied in a canine cancellous ulnar segmental-replacement model. Frozen bone that was exchanged across strong and weak transplantation barriers was evaluated histologically and radiographically at thirteen and twenty-six weeks after grafting Histological grading criteria quantified the type of union at each end of the graft and the degree of remodeling of the marrow, spongiosa, and com-pacta. Radiographic grading criteria included the presence of union at each end of the graft and the de-gree of remodeling of the graft segment. In vitro studies for serum antibody and cell-mediated immunity were carried out by isotopic cytotoxicity methods at seven in-tervals during the twenty-six-week study period. His