HOX Genes and Oncogenesis

Copyright: © 2014 Procino A. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Class I homeobox genes are a family of transcription factors involved in human development, in the regulation of the cell memory program. Several HOX genes control the normal hematopoietic processes; recent evidence has demonstrated that deregulation of HOX genes plays a crucial role in the leukemogenesis and in many solid tumors mainly by means, the regulation of cell proliferation, cell death, metastasis and DNA repair