What Is the Role of Serial High-Sensitivity Troponin Measurements in Chronic Heart Failure?

In the past decade, there has been a literal explosion of studies examining cardiac biomarkers in heart failure (HF).2 Among the many reasons for this fact is that measurements of such biomarkers as natriuretic pep-tides (the current gold standard biomarker for HF diagnosis, prognosis, and management decision-making) are easy and safe to obtain, and they can po-tentially reveal important information about the pa-tient at the biological level. Another class of cardiac biomarkers, the cardiac troponins, also provide impor-tant information about the prognosis of patients with HF. Studies have shown that cardiac troponins are typ-ically measurable and sometimes frankly increased in HF patients, with values being closely linked with the severity of illness. Patients withmore severeHF usuall