Rapid Miniaturized Chromatographie Quality-Control Procedures for Tc-99m

To those of us in nuclear pharmacy responsible for the preparation of Tc-99m radiopharmaceuticals, a simple and rapid Chromatographie system is a valuable tool for the daily quality control of radiopharmaceuticals before the patient doses are dispensed. The technique recently pre sented by Zimmer and Pavel (/) is indeed simple and rapid and, as such, is representative of the "state of the art " in Tc-product quality control. However, some of the procedures described for the development and evaluation of the system need clarification. Figure 1 illustrates the 1 cm X 6 cm strip as described by Zimmer und Pavel. The solid lines at 1, 3, and 5 cm are the origin (or.), center line (c) and solvent front (sf), respectively. The dotted lines show where the strip was "cut into eight equal segments: four below the center lin