Comparison of plasminogen activator inhibitor-1 concentration in insulin-resistant versus insulin-sensitive healthy women. Arterioscler Thromb Vasc Biol

Abstract—The primary goal of this investigation was to see whether plasminogen activator inhibitor-1 (PAI-1) concentrations varied as a function of differences in insulin-mediated glucose disposal in 2 groups of healthy women matched for every other variable that might play a role in regulation of PAI-1. For this purpose, we recruited 32 healthy women, divided on the basis of their steady-state plasma glucose (SSPG) concentrations during the insulin suppression test into an insulin-resistant (SSPG5216612 mg/dL, n516) and an insulin-sensitive (9466 mg/dL, n516) group. PAI-1 antigen concentrations were significantly higher (2664 versus 1463 ng/mL, P,0.02) in the insulin-resistant group. In addition, fasting plasma insulin (1863 versus 1162 mU/mL, P,0.02) and triglyceride (160619 versus 93610 mg/dL, P,0.001) concentrations were higher in the insulin-resistant individuals, whereas HDL concentrations were lower (4463 versus 5863 mg/dL, P,0.005). However, the 2 groups were essentially identical in terms of age, menopausal status, hormone replacement therapy, body mass index (BMI), ratio of waist-to-hip girth, and blood pressure. When the experimental population was considered as 1 group, there were statistically significant correlations between PAI-1 antigen and the following variables: adjusting for differences in age and BMI, SSPG (r50.56, P,0.001)