Add to ORKGA series of 3-(alkylcarbamoyl)-2-aryl-1,2-dihydro-6,7-(methylenedioxy)-3H-quinazolin-4-ones, compounds 3 ± 6, were synthesized, and screened as anticonvulsant agents in DBA/2 mice against sound-induced seizure (Table). The new compounds were found to display anticonvulsant properties inferior to those of the known dehydro congeners 1 and 2. The binding affinities of 1 ± 6 at the AMPA and NMDA receptors were also evaluated. 1. Introduction
A new series of Quinazoline-oxadiazole analogues was designed, synthesized, and evaluated for antico...
A new series of quinazoline analogues was designed and synthesized to get the target compounds 18- 2...
Corresponding Author: Dr. Adnan A. Kadi Department of Pharmaceutical Chemistry, College of Pharmacy,...
A set of novel 1-aryl-6,7-methylenedioxy-3 H-quinazolin-4-(thi)ones (3a–f) has been designed and scr...
5-(4-Aminobenzyl)-7,9-dihydro-8H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-8-one(3) and 7,9-dihydro-5-[2...
A series of 1-substituted 2-[(4-aryl)-methyl]-4,5-methylenedioxybenzene derivatives (13-25), structu...
A series of 1-substituted 2-[(4-aryl)-methyl]-4,5-methylenedioxybenzene derivatives (13-25), structu...
Some novel fluorinated quinazolines (5a–j) were designed and synthesized to be evaluated for their a...
A series of 1-substituted 2-[(4-aryl)-methyl]-4,5-methylenedioxybenzene derivatives (13–25), structu...
Background: NMDA receptor specifically NR2B subunit plays a major role in eliptogenisis. Antagonists...
A series of 1-aryl-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-ones 2a-f, were synthesized ...
The synthesis and anticonvulsant activity of 1-aryl-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-ben...
The present work was carried out to synthesize a series of substituted quinazolinone semicarbazones ...
We have previously shown that 1-aryl-3,5-dihydro-7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones (3) ...
We have previously shown that 1-aryl-3,5-dihydro-7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones (3) ...
A new series of Quinazoline-oxadiazole analogues was designed, synthesized, and evaluated for antico...
A new series of quinazoline analogues was designed and synthesized to get the target compounds 18- 2...
Corresponding Author: Dr. Adnan A. Kadi Department of Pharmaceutical Chemistry, College of Pharmacy,...
A set of novel 1-aryl-6,7-methylenedioxy-3 H-quinazolin-4-(thi)ones (3a–f) has been designed and scr...
5-(4-Aminobenzyl)-7,9-dihydro-8H-[1,3]dioxolo[4,5-h][2,3]benzodiazepin-8-one(3) and 7,9-dihydro-5-[2...
A series of 1-substituted 2-[(4-aryl)-methyl]-4,5-methylenedioxybenzene derivatives (13-25), structu...
A series of 1-substituted 2-[(4-aryl)-methyl]-4,5-methylenedioxybenzene derivatives (13-25), structu...
Some novel fluorinated quinazolines (5a–j) were designed and synthesized to be evaluated for their a...
A series of 1-substituted 2-[(4-aryl)-methyl]-4,5-methylenedioxybenzene derivatives (13–25), structu...
Background: NMDA receptor specifically NR2B subunit plays a major role in eliptogenisis. Antagonists...
A series of 1-aryl-3,5-dihydro-7,8-ethylenedioxy-4H-2,3-benzodiazepin-4-ones 2a-f, were synthesized ...
The synthesis and anticonvulsant activity of 1-aryl-7,8-methylenedioxy-1,2,3,5-tetrahydro-4H-2,3-ben...
The present work was carried out to synthesize a series of substituted quinazolinone semicarbazones ...
We have previously shown that 1-aryl-3,5-dihydro-7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones (3) ...
We have previously shown that 1-aryl-3,5-dihydro-7,8-methylenedioxy-4H-2,3-benzodiazepin-4-ones (3) ...
A new series of Quinazoline-oxadiazole analogues was designed, synthesized, and evaluated for antico...
A new series of quinazoline analogues was designed and synthesized to get the target compounds 18- 2...
Corresponding Author: Dr. Adnan A. Kadi Department of Pharmaceutical Chemistry, College of Pharmacy,...