Add to ORKGEpigenetic regulation, including DNA methylation, plays an important role in several differentiation processes and possibly in adipocyte differentiation. To search for genes that show methylation change during adipogenesis, genome-wide DNA methylation analysis in insulin-induced adipogenesis of 3T3-L1 preadipocyte cells was performed using a method called microarray-based integrated analysis of methylation by isoschizomers (MIAMI). The MIAMI revealed that Hpa II sites of exon 1 in a Rho guanine nucleotide exchange factor 19 (ARHGEF19; WGEF) gene were demethylated during adipocyte differentiation of 3T3-L1 cells. Deletion of the region containing cytosine-guanine (CpG) sites that showed methylation change suppressed transcriptional activity ...
Metabolic syndrome (MetS) has been postulated to increase the risk for type 2 diabetes, cardiovascul...
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of...
Adipose tissue expansion in obesity leads to changes in the expression of adipokines, adipocyte-spec...
Epigenetic regulation, including DNA methylation, plays an important role in several differentiation...
Insight into the processes controlling adipogenesis is important in the battle against the obesity e...
Aim: To define the genomic distribution and function of DNA methylation changes during human adipoge...
Body fat distribution plays an important role in determining metabolic health. Whereas central obesi...
Body fat distribution plays an important role in determining metabolic health. Whereas central obesi...
The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic i...
Adipose tissue is not homogenous as individual fat depots display regional variation in their physio...
<p>A. CpG sites located on exon 1 and upstream region of WGEF gene. Circles and numbers indicate pos...
Genome-wide DNA methylation profiling was performed of human mesenchymal stem cells (hMSCs) differen...
Objective: DNA methylation may be a stable epigenetic contributor to defining fat cell lineage. Meth...
Park et al. shed light on the dynamics of DNA demethylation during adipocyte differentiation, which ...
NYGGF4, an obesity-related gene, is proposed to be involved in the development of insulin resistance...
Metabolic syndrome (MetS) has been postulated to increase the risk for type 2 diabetes, cardiovascul...
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of...
Adipose tissue expansion in obesity leads to changes in the expression of adipokines, adipocyte-spec...
Epigenetic regulation, including DNA methylation, plays an important role in several differentiation...
Insight into the processes controlling adipogenesis is important in the battle against the obesity e...
Aim: To define the genomic distribution and function of DNA methylation changes during human adipoge...
Body fat distribution plays an important role in determining metabolic health. Whereas central obesi...
Body fat distribution plays an important role in determining metabolic health. Whereas central obesi...
The twin epidemics of obesity and type 2 diabetes (T2D) are a serious health, social, and economic i...
Adipose tissue is not homogenous as individual fat depots display regional variation in their physio...
<p>A. CpG sites located on exon 1 and upstream region of WGEF gene. Circles and numbers indicate pos...
Genome-wide DNA methylation profiling was performed of human mesenchymal stem cells (hMSCs) differen...
Objective: DNA methylation may be a stable epigenetic contributor to defining fat cell lineage. Meth...
Park et al. shed light on the dynamics of DNA demethylation during adipocyte differentiation, which ...
NYGGF4, an obesity-related gene, is proposed to be involved in the development of insulin resistance...
Metabolic syndrome (MetS) has been postulated to increase the risk for type 2 diabetes, cardiovascul...
Approximately 1.5 billion people worldwide are overweight or affected by obesity, and are at risk of...
Adipose tissue expansion in obesity leads to changes in the expression of adipokines, adipocyte-spec...