0049-3848/83 $3.00 +.00 Printed in the USA. Copyright (c) '1983 Pergamon Press Ltd. All rights reserved. REEVALUATION OF SOME PROPERTIES OF FIBRINOGEN, PURIFIED FROI'{

In thls study we compared some propert ies of f ibr lnogens, obtained from normal adult and cord plasna. Fibrl-nogen preparations were made under conditions, whlch mlniml-ze proteolytlc breakilown l-n vltro. We were not able to demonstrate any signif icant dlf ferences between both purlf ied f ibr lnogens as to the effects of pl l and l-onic strength on i ts clott ing propert les, the K- for thrombin, SDS polyacrylarnlde gelelectrophoresis behaviour 6r carbohydrate content. Ilowever, the phosphorus content of cord flbrinogen was 3-4 tlmes hlgher than that of aclult fibrinogen. The acceleratiflg effect of calclum on the thronbin clotting tlroe was more pronounced for newborn cord pl-asma and for purlfied cord fibrinogen preparations as compared r.rlth adult flbrinogen. Thts ntght be explained by the higher phosphorus content of the cor