Hypotensive and Renal Vasodilator Effects of Carbocyclic Adenosine (Aristeromycin) in Anesthetized Spontaneously

Systemic arterial pressure and renal blood flow were measured in pentobarbital-anesthetized spontaneously hypertensive rats to assess the influence and mechanism of action of metabolically stable adenosine analogs on renal hemodynamics. (-)-Mstero-mycin (carbocydic adenosine; CA), a model CarbOCydliC nucleo-side, was characterized with respect to adenosine receptor pharmacology by comparison to the effects elicfted by the pro-totypic adenosine analogs 5’-N-ethyicarboxamide adenosine (NECA; an adenosine A1 and A2 receptor agonist) and N-cydo-hexyl adenosine (an adenosine A1 agonist). Intravenous bolus injections of CA and NECA caused dose-dependent hypotension and renal vasodilatation. Although CA and NECA were equally efficacious hypotensive agents, NECA was approximately 100-fold more potent than CA. CA was a more efficacious renal vasodilator than NECA. In contrast, at doses which had minima