Pediatric Acute Kidney Injury: Is the Addition of Gentamicin Worth the Risk?

Acute kidney injury (AKI) is not uncom-mon in children and is associated with significant morbidity and mortality [1–3]. Anti-infectives including aminoglycosides, acyclovir, foscarnet, and amphotericin B are commonly associated with nephrotoxic AKI. Aminoglycoside-induced AKI has been associated with poorer outcomes, even in non–critically ill children [4]. Although the addition of an aminoglyco-side occurs in clinical practice for the treatment of infections, compiled evi-dence demonstrates that this practice is not beneficial for indications such as sepsis and can instead be harmful du