doi: 10.1093/ndt/gfp192 Original Article Moderate-to-severe early-onset hyperuricaemia: a prognostic marker of long-term kidney transplant outcome

Background. Hyperuricaemia commonly occurs in re-nal transplant recipients (RTRs), but the effects of post-transplant hyperuricaemia on kidney transplant outcome have not been clearly established. This work was designed to explore the impact of hyperuricaemia on renal transplant outcome. Methods. The authors examined this issue by analysing the clinical outcome of 281 RTRs. Hyperuricaemia (defined as UA> 7.0 mg/dl in men and>6.0 mg/dl in women for at least two consecutive tests, n = 121) was classified as early onset (within 1 year of transplant, n = 90) or late onset (n= 31). Graft function was estimated using the MDRD Study Equation 7 (eGFRMDRD). Results. As late-onset hyperuricaemia was found to be in