Add to ORKG(Requests for offprints should be addressed to W G Beamer) A spontaneous autosomal recessive mutation causing dis-ordered morphogenesis of the adrenal cortex has been identified in DW/J inbred strain mice and named adreno-cortical dysplasia (acd). The acd mutant gene has been mapped just proximal to oligosyndactyly (Os) and esterase-1 (Es-1) in the central region of chromosome 8. Both male and female acd/acd mice are characterized by reduced survival, retarded growth, skin hyperpigmen-tation, poorly developed pelage and focal ureteral blockage leading to hydronephrosis. Morphometric measurements showed that acd/acd cortical cells and nuclei were increased sevenfold in volume; nuclei often showed a variety of inclusions. Cortical cells of ac...
Hereditary adrenocorticotropin (ACTH) resistance syndromes encompass the genetically heterogeneous i...
In an attempt to define novel genetic loci involved in the pathophysiology of primary aldosteronism,...
In an attempt to define novel genetic loci involved in the pathophysiology of primary aldosteronism,...
A spontaneous autosomal recessive mutation causing disordered morphogenesis of the adrenal cortex ha...
Adrenocortical dysplasia (acd) is a spontaneous autosomal recessive mouse mutant with developmental ...
Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused b
The formation of the adrenal cortex in humans is notable for the presence of two discrete zones, the...
SummaryTelomere dysfunction and shortening induce chromosomal instability and tumorigenesis. In this...
SummaryTelomere dysfunction and shortening induce chromosomal instability and tumorigenesis. In this...
The cortex of the adrenal gland is organized into concentric zones that produce distinct steroid hor...
The adrenal cortex is classically divided into three morphologically and biochemically distinct zone...
Hereditary adrenocorticotropin (ACTH) resistance syndromes encompass the genetically heterogeneous i...
Patients with congenital adrenal hyperplasia arising from mutations of 11_-hydroxylase, the final en...
Patients with congenital adrenal hyperplasia arising from mutations of 11_-hydroxylase, the final en...
AbstractAdrenocortical dysplasia (acd) is a spontaneous autosomal recessive mouse mutation that exhi...
Hereditary adrenocorticotropin (ACTH) resistance syndromes encompass the genetically heterogeneous i...
In an attempt to define novel genetic loci involved in the pathophysiology of primary aldosteronism,...
In an attempt to define novel genetic loci involved in the pathophysiology of primary aldosteronism,...
A spontaneous autosomal recessive mutation causing disordered morphogenesis of the adrenal cortex ha...
Adrenocortical dysplasia (acd) is a spontaneous autosomal recessive mouse mutant with developmental ...
Urogenital and caudal dysgenesis in adrenocortical dysplasia (acd) mice is caused b
The formation of the adrenal cortex in humans is notable for the presence of two discrete zones, the...
SummaryTelomere dysfunction and shortening induce chromosomal instability and tumorigenesis. In this...
SummaryTelomere dysfunction and shortening induce chromosomal instability and tumorigenesis. In this...
The cortex of the adrenal gland is organized into concentric zones that produce distinct steroid hor...
The adrenal cortex is classically divided into three morphologically and biochemically distinct zone...
Hereditary adrenocorticotropin (ACTH) resistance syndromes encompass the genetically heterogeneous i...
Patients with congenital adrenal hyperplasia arising from mutations of 11_-hydroxylase, the final en...
Patients with congenital adrenal hyperplasia arising from mutations of 11_-hydroxylase, the final en...
AbstractAdrenocortical dysplasia (acd) is a spontaneous autosomal recessive mouse mutation that exhi...
Hereditary adrenocorticotropin (ACTH) resistance syndromes encompass the genetically heterogeneous i...
In an attempt to define novel genetic loci involved in the pathophysiology of primary aldosteronism,...
In an attempt to define novel genetic loci involved in the pathophysiology of primary aldosteronism,...