Abuse of psychostimulants such as cocaine and amphet-amines has a tremendous social and economic impact. Al-though replacement therapies are offered for addiction to opi-oids, nicotine, and alcohol, there is no approved replacement treatment for psychostimulant addiction. Recent studies on an emerging group of benztropine- and rimcazole-based com-pounds provide hope that replacement therapies for cocaine and amphetamine addiction may come in the near future. A new study (p. 813) now investigates the molecular interaction of the benztropine and rimcazole compounds with their target, the dopamine transporter, and provides an intriguing explanation as to why use of these compounds, unlike cocaine, do not lead to locomotor stimulation and drug ...
The dopamine transporter (DAT) is a membrane protein that is responsible for the reuptake of dopamin...
RATIONALE N-substituted benztropine analogs are potent dopamine uptake inhibitors that display ph...
Despite huge advances in the neuroscience of substance abuse and dependence in the past 20 years, no...
Cocaine abuse is a serious health problem in many areas of the world, yet there are no proven effect...
Cocaine exerts its stimulatory effect by inhibiting the dopamine transporter (DAT). However, novel b...
Dopamine is a key neurotransmitter in the pathophysiology of substance dependence and low striatal d...
Benztropine (BZT) analogs, a family of high-affinity dopamine transporter ligands, are molecules tha...
The discovery and evaluation of high affinity dopamine transport inhibitors with low abuse liability...
The discovery and preclinical development of selective dopamine reuptake inhibitors as potential pha...
Behavioraleffectsof cocainethat are relevantto itsabusehave been associated with pharmacological act...
Analogs of benztropine (BZT) bind to the dopamine (DA) trans-porter and inhibit DA uptake but often ...
Rationale: The discriminative-stimulus effects of cocaine have been reported to be mediated by indir...
Cocaine, amphetamines and other psychostimulants inhibit synaptic dopamine uptake by interfering wit...
Monoamine transporter proteins are targets for many psychoactive compounds, including therapeutic an...
The fundamental principle that unites addictive drugs appears to be that each enhances synaptic dopa...
The dopamine transporter (DAT) is a membrane protein that is responsible for the reuptake of dopamin...
RATIONALE N-substituted benztropine analogs are potent dopamine uptake inhibitors that display ph...
Despite huge advances in the neuroscience of substance abuse and dependence in the past 20 years, no...
Cocaine abuse is a serious health problem in many areas of the world, yet there are no proven effect...
Cocaine exerts its stimulatory effect by inhibiting the dopamine transporter (DAT). However, novel b...
Dopamine is a key neurotransmitter in the pathophysiology of substance dependence and low striatal d...
Benztropine (BZT) analogs, a family of high-affinity dopamine transporter ligands, are molecules tha...
The discovery and evaluation of high affinity dopamine transport inhibitors with low abuse liability...
The discovery and preclinical development of selective dopamine reuptake inhibitors as potential pha...
Behavioraleffectsof cocainethat are relevantto itsabusehave been associated with pharmacological act...
Analogs of benztropine (BZT) bind to the dopamine (DA) trans-porter and inhibit DA uptake but often ...
Rationale: The discriminative-stimulus effects of cocaine have been reported to be mediated by indir...
Cocaine, amphetamines and other psychostimulants inhibit synaptic dopamine uptake by interfering wit...
Monoamine transporter proteins are targets for many psychoactive compounds, including therapeutic an...
The fundamental principle that unites addictive drugs appears to be that each enhances synaptic dopa...
The dopamine transporter (DAT) is a membrane protein that is responsible for the reuptake of dopamin...
RATIONALE N-substituted benztropine analogs are potent dopamine uptake inhibitors that display ph...
Despite huge advances in the neuroscience of substance abuse and dependence in the past 20 years, no...