Add to ORKGAbstract. Bax-mediated permeabilization of the outer mitochondrial membrane and release of apoptogenic factors into the cytosol are key events that occur during apoptosis. Likewise, apoptosis is associated with permeabilization of the lysosomal membrane and release of lysosomal cathepsins into the cytosol. This re-port identifies proteolytically active cathepsin D as an important component of apoptotic signaling follow-ing lysosomal membrane permeabilization in fibroblasts. Lysosome-mediated cell death is associated with degradation of Bax sequestering 14-3-3 proteins, cleavage of the Bax activator Bid, and translocation o
Lysosomal membrane permeabilization (LMP) occurs in response to a large variety of cell death stimul...
Abstract We have reported that chymotrypsin B (CtrB) is not just a digestive enzyme but is also stor...
it The molecular mechanism by which the Bd-2 family of proteins regulates the complex process of apo...
Abstract. Bax-mediated permeabilization of the outer mitochondrial membrane and release of apoptogen...
Abstract. Bax-mediated permeabilization of the outer mitochondrial membrane and release of apoptogen...
In the last decade, a tremendous gain in knowledge concerning the molecular events of apoptosis sign...
Lysosomes are acidic organelles that are critically involved in a number of physiological processes,...
One of two proapoptotic Bcl-2 proteins, Bak or Bax, is required to permeabilize the mitochondrial ou...
Mitochondrial outer membrane permeabilization (MOMP) constitutes one of the major checkpoint(s) of a...
The Bcl-2 family protein Bax is a key effector of apoptosis. Lovell et al. (2008) now describe the r...
For many years apoptosis research has focused on caspases and their putative role as sole executione...
Apoptosis plays a crucial role in multicellular organisms by preserving tissue homeostasis and remov...
For stressed cells to induce the mitochondrial pathway of apoptosis, a cohort of pro-apoptotic BCL-2...
For many years apoptosis research has focused on caspases and their putative role as sole executione...
AbstractDuring apoptosis, engagement of the mitochondrial pathway involves the permeabilization of t...
Lysosomal membrane permeabilization (LMP) occurs in response to a large variety of cell death stimul...
Abstract We have reported that chymotrypsin B (CtrB) is not just a digestive enzyme but is also stor...
it The molecular mechanism by which the Bd-2 family of proteins regulates the complex process of apo...
Abstract. Bax-mediated permeabilization of the outer mitochondrial membrane and release of apoptogen...
Abstract. Bax-mediated permeabilization of the outer mitochondrial membrane and release of apoptogen...
In the last decade, a tremendous gain in knowledge concerning the molecular events of apoptosis sign...
Lysosomes are acidic organelles that are critically involved in a number of physiological processes,...
One of two proapoptotic Bcl-2 proteins, Bak or Bax, is required to permeabilize the mitochondrial ou...
Mitochondrial outer membrane permeabilization (MOMP) constitutes one of the major checkpoint(s) of a...
The Bcl-2 family protein Bax is a key effector of apoptosis. Lovell et al. (2008) now describe the r...
For many years apoptosis research has focused on caspases and their putative role as sole executione...
Apoptosis plays a crucial role in multicellular organisms by preserving tissue homeostasis and remov...
For stressed cells to induce the mitochondrial pathway of apoptosis, a cohort of pro-apoptotic BCL-2...
For many years apoptosis research has focused on caspases and their putative role as sole executione...
AbstractDuring apoptosis, engagement of the mitochondrial pathway involves the permeabilization of t...
Lysosomal membrane permeabilization (LMP) occurs in response to a large variety of cell death stimul...
Abstract We have reported that chymotrypsin B (CtrB) is not just a digestive enzyme but is also stor...
it The molecular mechanism by which the Bd-2 family of proteins regulates the complex process of apo...