Add to ORKGAccepted for publication December 8,1993 Current research suggests there are genetic differences in sus-ceptibility to drug abuse. One way to examine this relationship Is to study inbred strains, such as Lewis (LEW) and Fischer 344 (F344) rats, that show differential biochemical and behavioral effects in response to psychoactive drugs. In the present study several behavioral effects of cocaine were compared in these strains, Including conditioned place preference (CPP), cord-tioned taste aversion and locomotor actMty. Cocaine CPP was greater In 11W rats than in F344 rats. In contrast, cocaine conditioned taste aversion did not differ between LEW and F344 rats, or did the locomotor activfty levels seen after the first cocaine administration....
Tested whether Lewis and Fischer rat strains differ in acquisition or maintenance of intravenous coc...
We previously developed rat experimental models based on the conditioned place preference (CPP) para...
Initial sensitivity to psychostimulants can predict subsequent use and abuse in humans. Acute locomo...
Current research suggests there are genetic differences in susceptibility to drug abuse. One way to ...
Lewis (LEW) and Fischer (F344) rats differ in a variety of measures. For example, LEW rats are more ...
Rat genotypes tentatively identified as addiction-prone or addiction-resistant on the basis of alcoh...
Lewis and F344 rat strains differ on a variety of physiological and behavioral endpoints, including ...
In previous studies, we have demonstrated that mice of the inbred strain C57BL/6J (C57) are more sus...
The use of inbred rat strains provides a tool to investigate the role of genetic factors in drug abu...
Conditioned place preference and locomotor sensitization are rodent behavioral models commonly used ...
ABSTRACTDrugs of abuse induce complex motivational states in their users which have been shown to va...
Abstract Background The expanding set of genomics tools available for inbred mouse strains has renew...
igh locomotor response to novelty is associated with ease of drug self-administration but does not p...
It has been speculated that an individual's response to novelty is a reliable predictor of its vulne...
Sensitivity to cocaine and its associated stimuli ("cues") are important factors in the development ...
Tested whether Lewis and Fischer rat strains differ in acquisition or maintenance of intravenous coc...
We previously developed rat experimental models based on the conditioned place preference (CPP) para...
Initial sensitivity to psychostimulants can predict subsequent use and abuse in humans. Acute locomo...
Current research suggests there are genetic differences in susceptibility to drug abuse. One way to ...
Lewis (LEW) and Fischer (F344) rats differ in a variety of measures. For example, LEW rats are more ...
Rat genotypes tentatively identified as addiction-prone or addiction-resistant on the basis of alcoh...
Lewis and F344 rat strains differ on a variety of physiological and behavioral endpoints, including ...
In previous studies, we have demonstrated that mice of the inbred strain C57BL/6J (C57) are more sus...
The use of inbred rat strains provides a tool to investigate the role of genetic factors in drug abu...
Conditioned place preference and locomotor sensitization are rodent behavioral models commonly used ...
ABSTRACTDrugs of abuse induce complex motivational states in their users which have been shown to va...
Abstract Background The expanding set of genomics tools available for inbred mouse strains has renew...
igh locomotor response to novelty is associated with ease of drug self-administration but does not p...
It has been speculated that an individual's response to novelty is a reliable predictor of its vulne...
Sensitivity to cocaine and its associated stimuli ("cues") are important factors in the development ...
Tested whether Lewis and Fischer rat strains differ in acquisition or maintenance of intravenous coc...
We previously developed rat experimental models based on the conditioned place preference (CPP) para...
Initial sensitivity to psychostimulants can predict subsequent use and abuse in humans. Acute locomo...