Add to ORKGAlthough a large number of immune epitopes have been identified in the influenza A virus (IAV) hemagglutinin (HA) protein using various experimental systems, it is unclear which are involved in protective immunity to natural infection in humans. We developed a data mining approach analyzing natural H1N1 human isolates to identify HA protein regions that may be targeted by the human immune system and can predict the evolution of IAV.We identified 16 amino acid sites experiencing diversifying selection during the evolution of prepandemic seasonal H1N1 strains and found that 11 sites were located in experimentally de-termined B-cell/antibody (Ab) epitopes, including three distinct neutralizing Caton epitopes: Sa, Sb, and Ca2 [A. J. Caton, G. G...
The emergence of a novel A(H1N1) strain in 2009 was the first influenza pandemic of the genomic age,...
[[abstract]]Human influenza viruses cause annual epidemics due to antigenic drifts in the hemaggluti...
[[abstract]]Human influenza viruses cause annual epidemics due to antigenic drifts in the hemaggluti...
The pandemic influenza virus (2009 H1N1) was recently introduced into the human population. The hema...
The pandemic influenza virus (2009 H1N1) was recently introduced into the human population. The hema...
The surface glycoprotein hemagglutinin (HA) helps the influenza A virus to evade the host immune sys...
The Pandemic (H1N1) 2009 is spreading to numerous countries and causing many human deaths. Although ...
In this paper we undertake an analysis of the antigenicity of influenza A virus hemagglutinin. We de...
In this paper we undertake an analysis of the antigenicity of influenza A virus hemagglutinin. We de...
The Pandemic (H1N1) 2009 is spreading to numerous countries and causing many human deaths. Although ...
<div><p>The emergence of a novel A(H1N1) strain in 2009 was the first influenza pandemic of the geno...
The emergence of a novel A(H1N1) strain in 2009 was the first influenza pandemic of the genomic age,...
The past pandemic strain H1N1 (A (H1N1)pdm09) has now become a common component of current seasonal ...
Background: The human influenza viruses undergo rapid evolution (especially in hemagglutinin (HA), a...
The past pandemic strain H1N1 (A (H1N1)pdm09) has now become a common component of current seasonal ...
The emergence of a novel A(H1N1) strain in 2009 was the first influenza pandemic of the genomic age,...
[[abstract]]Human influenza viruses cause annual epidemics due to antigenic drifts in the hemaggluti...
[[abstract]]Human influenza viruses cause annual epidemics due to antigenic drifts in the hemaggluti...
The pandemic influenza virus (2009 H1N1) was recently introduced into the human population. The hema...
The pandemic influenza virus (2009 H1N1) was recently introduced into the human population. The hema...
The surface glycoprotein hemagglutinin (HA) helps the influenza A virus to evade the host immune sys...
The Pandemic (H1N1) 2009 is spreading to numerous countries and causing many human deaths. Although ...
In this paper we undertake an analysis of the antigenicity of influenza A virus hemagglutinin. We de...
In this paper we undertake an analysis of the antigenicity of influenza A virus hemagglutinin. We de...
The Pandemic (H1N1) 2009 is spreading to numerous countries and causing many human deaths. Although ...
<div><p>The emergence of a novel A(H1N1) strain in 2009 was the first influenza pandemic of the geno...
The emergence of a novel A(H1N1) strain in 2009 was the first influenza pandemic of the genomic age,...
The past pandemic strain H1N1 (A (H1N1)pdm09) has now become a common component of current seasonal ...
Background: The human influenza viruses undergo rapid evolution (especially in hemagglutinin (HA), a...
The past pandemic strain H1N1 (A (H1N1)pdm09) has now become a common component of current seasonal ...
The emergence of a novel A(H1N1) strain in 2009 was the first influenza pandemic of the genomic age,...
[[abstract]]Human influenza viruses cause annual epidemics due to antigenic drifts in the hemaggluti...
[[abstract]]Human influenza viruses cause annual epidemics due to antigenic drifts in the hemaggluti...