Transmission of Infectious Mononucleosis by Transfusion of Pre-lllness Plasma

The transmission of infectious mononucleosis by transfusion of platelet-rich plasma is reported. Seventeen days after the donation of the plasma to his leukemic brother, the donor developed clinical signs of infectious mononucleosis. The disease manifested itself in the leukemic brother 30 days after he received the plasma, at which time specific heterophile antibodies were noted, as well as Epstein-Barr virus antibody seroconversion. The infectivity of pre-illness plasma in infectious mononucleosis is suggested. INFECTIOUS MONONUCLEOSIS is a self-limiting lym-phoproliferative and immunoproliferative disease characterized by classical clinical signs, morphological changes in the lymphocytes, and a specific rise in the heterophile antibodies. It is presumed to be usu