longitudinal MRI/MRSI study of corpus callosum

Backgrounds Atrophy of corpus callosum (CC), a white matter structure linking the two hemi-spheres, is commonly observed in multiple sclerosis (MS). However, the occurrence and processes leading to this alteration are not yet determined. Goal and methods To better characterize the onset and progression of CC atrophy from the early stage of MS, we performed a two-year follow-up magnetic resonance imaging/magnetic resonance spectroscopic imaging (MRI/MRSI) exploration of CC in 24 patients with clinically isolated syndrome. RI/MRSI spartate (NAA), creatine/phosphocreatine (Cr) and choline-containing compounds (Cho). A group o