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Objective: This study was designed to determine the effectiveness ofa group stress reduction program based on mindfulness meditation for patients with anxiety disorders. Method: The 22 study participants were screened with a structured clinical interview and found to meet the DSM-IH-R criteria for generalized anxiety disorder or panic disorder with or without agora-phobia. Assessments, including self-ratings and therapists ’ ratings, were obtained weekly be-f ore and during the meditation-based stress reduction and relaxation program and monthly during the 3-month follow-up period. Results: Repeated measures analyses ofvariance docu-mented significant reductions in anxiety and depression scores after treatment for 20 of the subjects-changes that were maintained at follow-up. The number of subjects experiencing panic symptoms was also substantially reduced. A comparison of the study subjects with a group ofnonstudy participants in the program who met the initial screening criteria for entry into the study showed that both groups achieved similiar reductions in anxiety scores on the SCL-90-R and on the Medical Symptom Checklist, suggesting generalizability of the study f indings. Conclusions: A group mindfulness meditation training program can effectively re-duce symptoms ofanxiety and panic and can help maintain these reductions in patients wit