SUMMARY

Objective. To investigate whether the use of intensive glycemic control versus conventional therapy during the Diabetes Control and Complications Trial (DCCT) affected the long-term incidence of cardiovascular disease (CVD). Design. The DCCT randomly assigned 1,441 patients with type 1 diabetes to intensive or conventional therapy, treat-ing them for a mean of 6.5 years. Ninety-three percent were subsequently followed for CVD in the Epidemiology of Diabetes Interventions and Complications (EDIC) study