S. GIMELLI+ L.VENEGONI

Molecular biology of cutaneous T-cell lymphomas Actually, the diagnostic proce-dures for the molecular diagno-sis and monitoring of a T-cell neoplasia on tissue sections or DNA extracted from cutaneous lesions include: a. the demonstration of clonality (a clone is a group of cells expanded from a single cell), of the lymphoid tissue infiltrates, by using molecular probes specific for the T-cell receptors (TCR); TCR-Gamma, TCR-Beta and, more rarely TCR-Delta subunits. This analy-sis, in the past done by using Southern-Blot method, may be performed b