CLINICAL REPORT Microcephaly, Intellectual Impairment, Bilateral

drome and blepharo-chelio-dontic (BCD) syndrome include the aberrant growthof eyelashes from themeibomianglands, known asdistichiasis. LD is anautosomaldominant syndromeprimarily characterized by distichiasis and the onset of lymphedema usually during puberty. Mutations in the forkhead transcription factor FOXC2 are the only known cause of LD. BCD syndrome consists of autosomal dominant abnormalities of the eyelid, lip, and teeth, and the etiology remains unknown. In this report, we describe a proband that presented with distichiasis, microceph-aly, bilateral grade IV vesicoureteral reflux requiring ureteral re-implantation, mild intellectual impairment and apparent glomuvenous malformations (GVM). Distichiasis was present in three generations of the proband’smaternal side of the family. The GVMs were severe in the proband, and maternal family members exhibited lower extremity varicosities of variable de