Regular Article TRANSPLANTATION Role of naive-derived T memory stem cells in T-cell reconstitution

TSCM are abundant early after allogeneic hematopoietic stem cell transplantation and derive from naive T cells that survived pt-Cy. Pt-Cy allows the generation of donor primary and recall responses in transplanted patients, even in the presence of persistent antigen. Early T-cell reconstitution following allogeneic transplantation depends on the persis-tence and function of T cells that are adoptively transferredwith the graft. Posttransplant cyclophosphamide (pt-Cy) effectively prevents alloreactive responses from unmanipu-lated grafts, but its effect on subsequent immune reconstitution remains undetermined. Here, we show that T memory stem cells (TSCM), which demonstrated superior reconsti