C. Selton-Suty,3 B. Hoen,1,3 and the International Collaboration on Endocarditis Study Group

Staphylococcus aureus prosthetic valve infective endocarditis (SA-PVIE) is associated with a high mortality rate, but prog-nostic factors have not been clearly elucidated. The Inter-national Collaboration on Endocarditis merged database (ICE-MD) contained 2212 cases of definite infective endo-carditis (as defined using the Duke criteria), 61 of which were SA-PVIE. Overall mortality rate was 47.5%, stroke was associated with an increased risk of death, and early valve replacement was not associated with a significant survival benefit in the whole population; however, patients who de-veloped cardiac complications and underwent early valve re-placement had the lowest mortality rate (28.6%). Prosthetic valve (PV) infective endocarditis (IE) is a seriou