Original Contribution Association of Sequence Variants on Chromosomes 20, 11, and 5 (20q13.33, 11q23.3, and 5p15.33) With Glioma Susceptibility in a Chinese Population

Two genome-wide association studies of glioma in European populations identified 14 genetic variants strongly associated with risk of glioma, but it is unknown whether these variants are associated with glioma risk in Asian populations. The authors genotyped these 14 variants in 976 glioma patients and 1,057 control subjects to evaluate their associations with risk of glioma, particularly high-grade glioma (glioblastoma; n 312), in a Chinese pop-ulation (2004–2009). Overall, the authors identified 3 susceptibility loci for glioma risk at 20q13.33 (RTEL1 rs6010620 (P 2.79 3 106)), 11q23.3 (PHLDB1 rs498872 (P 3.8 3 106)), and 5p15.33 (TERT rs2736100 (P 3.69 3 104)) in this study population; these loci were also associated with glioblastoma risk (20q13.33: RTEL1 rs6010620 (P 3.573 107); 11q23.3: PHLDB1 rs498872 (P 7.243 103); 5p15.33: TERT rs2736100 and TERT rs2736098 (P 1.213 104 and P 2.843 104, respectively)). This study provides further evidence for 3 glioma susceptibility regions at 20q13.33, 11q23.3, and 5p15.33 in Chinese populations. Asian continental ancestry group; association; genetics; genetic variation; genome-wide association study; glioma; polymorphism, single nucleotide Abbreviations: CI, confidence interval; GWAS, genome-wide association study(ies); OR, odds ratio; SNP, single nucleotide polymorphism. Although primary brain tumors are relatively rare (5%