Consensus statement on the standardization and evaluation of growth hormone and insulin-like growth factor assays

Growth hormone (GH) and insulin-like growth factor I (IGF-I) measurements are widely used in the diagno-sis of disorders of GH secretion, evaluation of children with short stature from multiple causes, management of disorders that lead to nutritional insufficiency or catabolism, and monitoring both GH and IGF-I re-placement therapy. Therefore, there is an ongoing need for accurate and precise measurements of these 2 pep-tide hormones. Representatives of the Growth Hor-mone Research Society, the IGF Society, and the IFCC convened an international workshop to review assay standardization, requirements for improving assay comparability, variables that affect assay interpreta-tion, technical factors affecting assay performance, as-say validation criteria, and the development and use o