Reprints and permission:

jfms.com A 13-year-old female spayed domestic shorthair cat presented to the University of Florida Small Animal Hospital for investigation of increased concentrations of the liver enzymes, alanine transaminase (ALT) and alka-line phosphatase (ALP). The owner had noted a mild decrease in appetite 2 months before presentation. At that time, serum concentrations of ALT [452 U/l; refer-ence interval (RI) 12–130 U/l], and ALP (174 U/l; RI 14–111 U/l) were increased. Other blood chemistries, a complete blood count (CBC) and total thyroxine con-centrations proved normal; feline immunodeficiency virus antibody and feline leukemia virus antigen tests were negative. Empirical treatment with unknown doses of S-adenosylmethionine and silybin (Denamarin