Complex N-Heterocycle Synthesis via Iron-Catalyzed,

The manipulation of traditionally unreactive functional groups is of paramount importance in modern chemical synthesis. We have developed an iron-dipyrrinato catalyst that leverages the reactivity of iron-borne metal-ligand multiple bonds to promote the direct amination of aliphatic C–H bonds. Exposure of organic azides to the iron dipyrrinato catalyst furnishes saturated, cyclic amine products (N-heterocycles) bearing complex core-substitution patterns. This study highlights the development of C–H bond functionalization chemistry for the formation of saturated, cyclic amine products and should find broad application in the context of both pharmaceuticals and natural product synthesis. Saturated, cyclic amines (N-heterocycles)are important building blocks for the syn-thesis of biologically active natural products, pharmaceutical agents, andmaterials. Current strat-egies for constructing saturated N-heterocycles are heavily dependent on functional group ex-change, leading to inefficient synthetic protocols with poor atom economy and waste generation. A streamlined synthetic approach to this produc