Antigen-binding idiotypic receptors from T lymphocytes, an analysis of their biochemistry genetics and use as immunogens to produce specific immune tolerance. Cold Spnng Harbor Symp Quant. Biol

Thymus-dependent (T) lymphocytes are able to recognize antigen in a highly discriminatory manner (for discussion, see Janeway 1976). Unlike the receptors on B lymphocytes, which behave more or less like conventional immunoglobulin (Ig) molecules, the nature of the antigen-binding receptors on T cells has long constituted an enigma (Crone et al. 1972). Two major sets of genes have been implied to participate in the generation of the antigen-binding structures on T cells. One set of genes comprises the so-called immune-response (Ir) genes associated with the major histocom-patibility (MHC) complex locus of the species (Benacerraf and McDevitt 1972). These Ir genes have frequently been found to govern whether