Re: Microsatellite Instability and BRAF Mutation Testing in Colorectal

Lochhead et al. recently reported the com-bined prognostic role of BRAF V600E muta-tion and microsatellite instability (MSI) in 1253 colorectal cancer patients with a median follow-up of 8.2 years (1). In their stage-strat-ified multivariable analyses that included age, year of diagnosis, body mass index (BMI), tumor differentiation, and LINE-1 meth-ylation as additional covariables, they found that, compared with the microsatellite stable (MSS)/BRAF–wild-type group, MSS/BRAF-mutant, MSI-high/BRAF-mutant, and MSI-high/BRAF–wild-type groups showed colorectal cancer-specific mortality hazard ratios (HR) of 1.60 (95 % confidence inter