Special Reports Strengthening the Reporting of Genetic Risk Prediction Studies: The GRIPS Statement

The recent successes of genome-wide association studies andthe promises of whole genome sequencing fuel interest in the translation of this new wave of basic genetic knowledge to health care practice. Knowledge about genetic risk factors may be used to target diagnostic, preventive, and therapeutic inter-ventions for complex disorders based on a person’s genetic risk, or to complement existing risk models based on classical nongenetic factors, such as the Framingham risk score for cardiovascular disease. Implementation of genetic risk predic-tion in health care requires a series of studies that encompass all phases of translational research,1,2 starting with a comprehensive evaluation of genetic risk prediction. With increasing numbers of discovered genetic markers that can be used in future genetic risk prediction studies, it is crucial to enhance the quality of the reporting of these studies, since valid interpretation could be compromised by the lac