Accelerated Neointima Formation After Vascular Injury in Mice With Stromelysin-3 (MMP-11) Gene Inactivation

Abstract—The hypothesis that stromelysin-3 (MMP-11), a unique member of the matrix metalloproteinase (MMP) family, plays a role in neointima formation was tested with the use of a vascular injury model in wild-type (MMP-111/1) and MMP-11–deficient (MMP-112/2) mice. Neointima formation 2 to 3 weeks after electric injury of the femoral artery wa