Pathogen resistance in Caenorhabditis elegans is a model for studying innate immunity. Several conserved activators in the p38 PMK-1 pathway have been identified and are required for pathogen resistance to the bacterium Pseudomonas aeroginosa. Thus far, screens have been performed to identify mutants that are susceptible to pathogen infection. Here, I will discuss a mek-1 suppressor screen that was performed to look for more components of the p38 PMK-1 pathway. Aided by the agls219 reporter, mutants with high levels of GFP expression were isolated and screened for suppression of the Esp phenotype of mek-1. Several independently isolated strong suppressor mutants were isolated and separated into possible complementation groups using pooled l...
Our laboratories have studied the mecha-nisms of aging (1, 2) and immune function (3) in Caenorhabdi...
<p>Recently, the study of invertebrate innate immunity has garnered considerable attention after the...
The opportunistic pathogen Pseudomonas aeruginosa utilizes a variety of virulence factors to infect ...
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 2007.Includes bibliographica...
The PMK-1 p38 mitogen-activated protein kinase pathway and the DAF-2–DAF-16 insulin signaling pathwa...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2014.Cataloged from PD...
Although Caenorhabditis elegans exhibits specific innate immune responses to microbial challenge, pa...
The Gram-negative bacterium Photorhabdus luminescens which symbiotically associates with the entomop...
The innate immune system is critical in protecting against foreign invaders and can be activated by ...
The innate immune response is an important component of wound healing, but must be negatively regula...
In a previous genetic screen for Caenorhabditis elegans mutants that survive in the presence of an a...
Most of the bacteria we encounter everyday do us no harm and many are even beneficial. Those that do...
Discriminating pathogenic bacteria from bacteria used as a food source is key to Caenorhabidits eleg...
When C. elegans, a species of roundworm, are stressed by their environment by, for example, nutrient...
The human opportunistic pathogen, Pseudomonas aeruginosa PAO1, has been shown to kill the nematode ...
Our laboratories have studied the mecha-nisms of aging (1, 2) and immune function (3) in Caenorhabdi...
<p>Recently, the study of invertebrate innate immunity has garnered considerable attention after the...
The opportunistic pathogen Pseudomonas aeruginosa utilizes a variety of virulence factors to infect ...
Thesis (S.M.)--Massachusetts Institute of Technology, Dept. of Biology, 2007.Includes bibliographica...
The PMK-1 p38 mitogen-activated protein kinase pathway and the DAF-2–DAF-16 insulin signaling pathwa...
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Biology, 2014.Cataloged from PD...
Although Caenorhabditis elegans exhibits specific innate immune responses to microbial challenge, pa...
The Gram-negative bacterium Photorhabdus luminescens which symbiotically associates with the entomop...
The innate immune system is critical in protecting against foreign invaders and can be activated by ...
The innate immune response is an important component of wound healing, but must be negatively regula...
In a previous genetic screen for Caenorhabditis elegans mutants that survive in the presence of an a...
Most of the bacteria we encounter everyday do us no harm and many are even beneficial. Those that do...
Discriminating pathogenic bacteria from bacteria used as a food source is key to Caenorhabidits eleg...
When C. elegans, a species of roundworm, are stressed by their environment by, for example, nutrient...
The human opportunistic pathogen, Pseudomonas aeruginosa PAO1, has been shown to kill the nematode ...
Our laboratories have studied the mecha-nisms of aging (1, 2) and immune function (3) in Caenorhabdi...
<p>Recently, the study of invertebrate innate immunity has garnered considerable attention after the...
The opportunistic pathogen Pseudomonas aeruginosa utilizes a variety of virulence factors to infect ...