Yeast: a simple model system to study complex phenomena of aneuploidy

adaptation; chromosomal instability; gene expression; karyotyping; phenotypic variation. Aneuploidy, the state of having a chromosome number different from a multi-ple of the haploid number, has been associated with diseases and developmen-tal disorders. The role of aneuploidy in human disease pathology, especially in cancer, has been a subject of much attention and debate over the last century due to the intrinsic complexity of the phenomena and experimental challenges. Over the last decade, yeast has been an invaluable model for driving discoveries about the genetic and molecular aspects of aneuploidy. The understanding of aneuploidy has been significantly improved owing to the methods for selec-tively generating aneuploid yeast strains without causing other genetic changes, techniques for detecting aneuploidy, and cutting-edge genetics and ‘omics’ approaches. In this review, we discuss the contribution of studies in yeast to current knowledge about aneuploidy. Special emphasis is placed on experimen-tal features that make yeast a simpler and efficient model to investigate the complex questions in the field of aneuploidy