Add to ORKGIt has been previously proposed that adenosine plays an impor-tant role in the pathogenesis of asthma. The proposedmechanism of action for nucleoside adenosine is to activate A2B adenosine receptors (AR) and to indirectly modulate levels of mediators in the lung. In vivo data supporting the role of A2B AR in airway reactivity and inflammation in allergic animal models are lacking. The present study describes the effects of a selective A2B AR antag-onist, CVT-6883 [3-ethyl-1-propyl-8-[1-(3-trifluoromethylbenzyl)-1H-pyrazol-4-yl]-3,7-dihydropurine-2,6-dione], on airway reactiv-ity and inflammation in an allergic mouse model of asthma. Mice were sensitized with ragweed (i.p.) on days 1 and 6 and chal-lenged with 0.5 % ragweed on days 11, 12, a...
Endogenous adenosine is released in asthmatic patients’ lungs by inhaled allergen,however,its exact ...
Background: Adenosine is a signalling nucleoside that has been proposed to contribute to the pathoge...
Adenosine, an endogenous signaling nucleoside that modulates many physiological processes has been i...
Adenosine is a powerful bronchoconstrictor of asthmatic, but not normal, airways. In vitro studies o...
Background: Adenosine receptor activation is suggested to play a role in asthmatic airway inflammati...
Adenosine participates to asthma physiopathology by signaling through more than just one receptor su...
There are pharmacological evidences that A(2B) receptors are involved in inflammatory processes, su...
Effect of a specific and selective A2B adenosine receptor antagonist on adenosine agonist, AMP and a...
AbstractEpidemiological studies have shown a positive correlation between poor lung function and res...
Growing evidence emphasizes that the purine nucleoside adenosine plays an active role as local regul...
Asthma is a chronic inflammatory disease of the airways that involves many cell types, amongst which...
Background Inhaled adenosine causes bronchoconstriction in asthmatics and may modulate inflammatory ...
Adenosine, an important signaling molecule in asthma, produces bronchoconstriction in asthmatics. Ad...
Adenosine has been implicated to play a role in inflammatory processes associated with asthma. Most ...
This study was aimed at characterizing the role of adenosine receptor subtypes in the contractility ...
Endogenous adenosine is released in asthmatic patients’ lungs by inhaled allergen,however,its exact ...
Background: Adenosine is a signalling nucleoside that has been proposed to contribute to the pathoge...
Adenosine, an endogenous signaling nucleoside that modulates many physiological processes has been i...
Adenosine is a powerful bronchoconstrictor of asthmatic, but not normal, airways. In vitro studies o...
Background: Adenosine receptor activation is suggested to play a role in asthmatic airway inflammati...
Adenosine participates to asthma physiopathology by signaling through more than just one receptor su...
There are pharmacological evidences that A(2B) receptors are involved in inflammatory processes, su...
Effect of a specific and selective A2B adenosine receptor antagonist on adenosine agonist, AMP and a...
AbstractEpidemiological studies have shown a positive correlation between poor lung function and res...
Growing evidence emphasizes that the purine nucleoside adenosine plays an active role as local regul...
Asthma is a chronic inflammatory disease of the airways that involves many cell types, amongst which...
Background Inhaled adenosine causes bronchoconstriction in asthmatics and may modulate inflammatory ...
Adenosine, an important signaling molecule in asthma, produces bronchoconstriction in asthmatics. Ad...
Adenosine has been implicated to play a role in inflammatory processes associated with asthma. Most ...
This study was aimed at characterizing the role of adenosine receptor subtypes in the contractility ...
Endogenous adenosine is released in asthmatic patients’ lungs by inhaled allergen,however,its exact ...
Background: Adenosine is a signalling nucleoside that has been proposed to contribute to the pathoge...
Adenosine, an endogenous signaling nucleoside that modulates many physiological processes has been i...