3-D CT Imaging of Pathological Bone Changes in a Rat Model of Adjuvant-Induced Arthritis 3-D CT Imaging of Pathological Bone Changes in a Rat Model of Adjuvant-Induced Arthritis

Computed tomography (CT) is a medical imaging method employing tomography. CT is a 3-Dimensional (3-D) radiographic imaging technique, which is not suited for assessment of inflammation, but can be considered a reference method for assessment of bone damage, due to its direct 3-D visualization of calcified tissue. In this study of pathological joint changes in a rat model of adjuvant-induced arthritis (AIA) and quality analysis of bone destructions were performed by 3-Dimensional computed tomography images. These data demonstrate that the destructive progression of disease in a rat AIA model can be quantified using 3-D CT image analysis, which allows assessment of arthritic disease status and efficacy of experimental therapeutic agents. Key word: 3-D CT, adjuvant-induced arthritis, rat I