Studies with Flavin Analogs Provide Evidence That a Protonated Reduced FMN Is the Substrate-induced Transient Intermediate in the Reaction of Escherichia coli Chorismate Synthase*

Publication date

October 2016

Abstract

Chorismate synthase catalyzes the 1,4-elimination of phosphate and the C-(6-pro-R) hydrogen from 5-enol-pyruvylshikimate 3-phosphate (EPSP) to generate cho-rismate. Although this reaction does not involve an overall change in redox state, the enzyme requires re-duced FMN. To investigate the role of the flavin in ca-talysis we have employed chemically modified flavins: 1

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Studies with Flavin Analogs Provide Evidence That a Protonated Reduced FMN Is the Substrate-induced Transient Intermediate in the Reaction of Escherichia coli Chorismate Synthase*

Abstract

Extracted data

Studies with Flavin Analogs Provide Evidence That a Protonated Reduced FMN Is the Substrate-induced Transient Intermediate in the Reaction of Escherichia coli Chorismate Synthase*

Abstract

Extracted data

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