c ical Re

Abstract Background: The high prevalence of colorectal carcinoma (CRC) is a driver to under-and cyclooxygenase in cancer pathogenesis is unclear. COX-2 regulation of proliferation, apoptosis, Aim: To determine the significance of COX-2 and b-catenin expression in colorectal carcinogenesis and prognosis. sion was interpreted in relation to adjacent normal colonic mucosa and analyzed in correlation with iod of 24 months. 2 was completely oth protei whereas b-cant relati between pathological grade and both b-catenin, and COX-2 positivity scores, being at the higher higher tumor stage and LN metastasis. Both COX-2 and b-catenin expression correlated with a higher incidence of shorter disease free survival